Last Update:
August 18, 2024

QQ Q

          2024

1. Kong S, Zhu M, Scarpin MR, Pan D, Jia L, Martinez RE, Alamos S, Vadde BVL, Garcia HG, Qian SB, Brunkard JO, Roeder AHK. DRMY1 promotes robust morphogenesis by sustaining translation of a hormone signaling protein. Dev Cell. 2024 (in press)
   
   
2. We X. and Qian SB. eIF4E integrates into stress response. Mol Cell. 2024, 84(11):2009-2010. Pubmed & PDF
   

2023



3.  Mao Y, Jia L, Dong L, Shu XE, Qian SB. Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation. Nat Struct Mol Biol. 2023, 30(11):1816-1825. Pubmed & PDF
   

Highlighted in the cover image



4. Uematsu S, Qian SB. Hijacking host ribosomes via tRNA mimicry. Nat Cell Biol. 2023, 25(11):1562-1563. Pubmed & PDF
   
   
5. Swanda RV, Ji Q, Yan J, Dong L, Mao Y, Uematsu S, Dong Y, and Qian SB. Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response. Mol Cell 2023, 83(18):3347-3359.e9. Pubmed & PDF
   
   
6. Zhang F, Ji Q, Chaturvedi J, Morales M, Mao Y, Meng X, Dong L, Deng J, Qian SB, and Xiang Y. Human SAMD9 is a virus-activatable anticodon nuclease inhibiting codon-specific protein synthesis. Sci Adv 2023, 9(23):eadh8502. doi: 10.1126/sciadv.adh8502. Pubmed & PDF
   
   
7. Kong S, Zhu M, Scarpin MR, Pan D, Jia L, Martinez RE, Alamos S, Vadde BVL, Garcia HG, Qian SB, Brunkard JO, Roeder AHK. DRMY1 promotes robust morphogenesis by sustaining translation of a hormone signaling protein. bioRxiv. 2023 Apr 7:2023.04.07.536060. doi: 10.1101/2023.04.07.536060. Preprint.
   
   
8. Mao Y and Qian SB, Making sense of mRNA translational "noise". Semin Cell Dev Biol. 2024, 15;154(Pt B):114-122. Pubmed & PDF
   
   

2022

9. Liu XM, Mao Y, Wang S, Zhou J, Qian SB. METTL3 modulates chromatin and transcription dynamics during cell fate transition. Cell Mol Life Sci. 2022; 79(11):559. doi: 10.1007/s00018-022-04590-x. Pubmed & PDF
    
10. Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M. Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Cell Rep. 2022; 40(3) 111092. Pubmed & PDF
    
    
11. Peng S, Meng X, Zhang F, Pathak PK, Chaturvedi J, Coronado J, Morales M, Mao Y, Qian SB, Deng J, Xiang Y. Structure and function of an effector domain in antiviral factors and tumor suppressors SAMD9 and SAMD9L. Proc Natl Acad Sci U S A. 2022; 119(4):e2116550119. Pubmed & PDF

2021

12. Shu XE, Mao Y, Jia L, Qian SB. Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress. Nat Chem Biol 2021; 18(2): 134-141. Pubmed & PDF
    
    
13. Gu Y, Mao Y, Jia L, Dong L, Qian SB. Bi-directional ribosome scanning controls the stringency of start codon selection. Nat Commun. 2021; 12(1):6604. doi: 10.1038/s41467-021-26923-3. Pubmed & PDF
    

	Highlighted in Faculty Opinions

14. Jia L, Qian SB. Therapeutic mRNA Engineering from Head to Tail. Acc Chem Res. 2021; 54(23):4272-4282. Pubmed & PDF
    
    
15. Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M. Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress. Mol Cell. 2021; 81(20):4191-4208.e8. Pubmed & PDF
     
16. Ji Q, Zong X, Mao Y, Qian SB. A heat shock-responsive lncRNA Heat acts as a HSF1-directed transcriptional brake via m6A modification. Proc Natl Acad Sci USA 2021; 118(25):e2102175118. Pubmed & PDF
    
    
17. Liu XM, Qian SB. Targeted RNA m6A Editing Using Engineered CRISPR-Cas9 Conjugates. Methods Mol Biol. 2021; 2298:399-414. doi: 10.1007/978-1-0716-1374-0_23. Pubmed & PDF
    
    
18. Zhang X, Ji Q, Qian SB. Reply to: Reevaluating the role of human mitochondrial uL18m in the cytosolic stress response.Nat Struct Mol Biol. 2021. 28(6):476-477. Pubmed & PDF
    
    
19. Qiu J, Qian SB.  Poly-A Tailing and Adaptor Ligation Methods for Ribo-Seq Library Construction. Methods Mol Biol. 2021; 2252:221-237. doi: 10.1007/978-1-0716-1150-0_10. Pubmed & PDF
    
    
20. Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian SB, Gan B. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021; 12(1):1589. doi: 10.1038/s41467-021-21841-w. Pubmed & PDF
    
    
21. Dong L, Mao Y, Zhou A, Liu X, Zhou J, Wan J, and Qian SB. Relaxed initiation pausing of ribosomes drives oncogenic translation. Sci Adv 2021; 17;7(8):eabd6927. doi: 10.1126/sciadv.abd6927. Pubmed & PDF.
     
22. Jia L and Qian SB. A Versatile eIF3d in Translational Control of Stress Adaptation. Mol Cell 2021;81(1):10-12. doi: 10.1016/j.molcel.2020.12.016.). Pubmed & PDF
    QQ QQ
    2020
    QQ QQ
23. Liu XM, Wang S, Gan X, Qian SB, Zhou J. Fluorescein-based monitoring of RNA N6-methyladenosine at single-nucleotide resolution. J Mol Cell Biol 2020; doi: 10.1093/jmcb/mjaa057 Pubmed
     
24. Mittenbühler MJ, Saedler K, Nolte H, Kern L, Zhou J,Qian SB, Meder L, Ullrich RT, Brüning JC, Wunderlich FT. Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Mol Metab 2020; doi: 10.1016/j.molmet.2020.101085. Pubmed & PDF.
    QQ QQ
25. Jia L, Mao Y, Ji Q, Dersh D, Yewdell JW, Qian SB. Decoding mRNA translatability and stability from the 5'UTR. Nat Struct Mol Biol 2020; 27(9):814-821. Pubmed & PDF.
    

	Highlighted in News & Views (PDF)

26. Shu XE, V Swanda R, Qian SB. Nutrient control of mRNA translation. Annu Rev Nutr 2020; doi: 10.1146/annurev-nutr-120919-041411. Pubmed & PDF.
    QQ QQ
27. Marker SC, King AP, Swanda RV, Vaughn B, Boros E, Qian SB, Wilson JJ. Exploring ovarian cancer cell resistance to rhenium anticancer complexes. Angew Chem Int Ed Engl 2020; 59(32):13391-13400. Pubmed & PDF.
    QQ QQ
28. Hu Y, Feng Y, Zhang L, Jia Y, Cai D, Qian SB, Du M, Zhao R. GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs. RNA Biol 2020; doi: 10.1080/15476286.2020.1736868. Pubmed & PDF.
    QQ QQ
29. Liu XM, Qian SB. Linking m6A to Wnt signaling. EMBO Rep. 2020; 21(4):e50097. Pubmed & PDF.
    QQ QQ
30. Orr MW, Mao Y, Storz G, Qian SB, Alternative ORFs and small ORFs: shedding light on the dark proteome. Nucleic Acids Res 2020; 48(3):1029-1042. Pubmed & PDF
    QQ QQ
31. Mao Y, Qian SB. Ribosome‐guided piRNA production. Nat Cell Biol 2020; 22(2):141‐142 Pubmed & PDF
    
    2019
    QQ QQ
32. Mao Y, Dong L, Liu XM, Guo J, Ma H, Shen B, Qian SB. m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2. Nat Commun 2019; 10(1):5332 Pubmed & PDF
    QQ QQ
33. Liu XM, Zhou J, Mao Y, Ji Q, Qian SB, Programmable RNA N6-methyladenosine editing using CRISPR/Cas9 conjugates. Nat Chem Biol 2019; 15(9):865-871 Pubmed & PDF

	Highlighted in News & Views (PDF)

34. King AP, Marker SC, Swanda RV, Woods JJ, Qian SB, Wilson JJ. A rhenium isonitrile complex induces unfolded protein response-mediated apoptosis in cancer cells. Chemistry 2019; 25(39):9206-9210 Pubmed
    QQ QQ
35. Wei J, Kishton RJ, Angel M, Conn CS, Dalla-Venezia N, Marcel V, Vincent A, Catez F, Ferré S, Ayadi L, Marchand V, Dersh D, Gibbs JS, Ivanov IP, Fridlyand N, Couté Y, Diaz JJ, Qian SB, Staudt LM, Restifo NP, Yewdell JW. Ribosomal proteins regulate MHC class I peptide generation for immunesurveillance. Mol Cell 2019; 73(6):1162-1173. PubMed & PDF
    QQ QQ
36. Liu XM, Qian SB, Assembly en route.Nat Struct Mol Biol 2019; 26(2) Pubmed & PDF.
    QQ QQ
37. Xi R, Tung KL, Wan J, Chen KY, Li F, Li X, Xin Y, Varanko A, Rakhilin N, Liu B, Qian SB, Su L, Han Y, Shen X. SENPS-mediated host defense response contains HBV replication and restores protein synthesis. PLOS One 2019; 14(1): e0209179. Pubmed & PDF.
    QQ QQ QQ QQ
    2018
    
    
38. Wan J, Gao X, Mao Y, Zhang X, Qian SB. A coding sequence-embeded principle governs translational reading frame fidelity. Research 2018; 2018:7089174. doi: 10.1155/2018/7089174. Pubmed & PDF
    QQ QQ
39. Zhang X, Shu XE, Qian SB. O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response. Nat Chem Biol 2018; 14(10):909-916. Pubmed & PDF
    QQ QQ
40. Anders M, Chelysheva I, Goebel I, Trenkner T, Zhou J, Mao Y, VerziniS, Qian SB, Ignatova Z. Dynamic m6A methylation facilitates mRNA triaging to stress granules. Life Sci Alliance 2018; 1(4):e20180013. Pubmed & PDF
    QQ QQ
41. Mazor KM, Dong L, Mao Y, Swanda RV, Qian SB, Stipanuk MH. Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine. Sci Reports 2018; 8(1):8076. PubMed & PDF
    
    
42. Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB. N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response. Mol Cell 2018; 69(4):636-647. PubMed & PDF
    

	Featured on the cover (image)		Highlighted in Previews (PDF)

2017


43. Li X, Xiong X, Zhang M, Wang K, Chen Y, Zhou J, Mao Y, Lv J, Yi D, Chen XW, Wang C, Qian SB, Yi C. Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Mol Cell 2017; 68(5):993-1005. PubMed & PDF
    

	Highlighted in Previews (PDF)

44. Coots RA, Liu XM, Mao Y, Dong L, Zhou J, Wan J, Zhang X, Qian SB*. m6A facilitates eIF4F-independent mRNA translation. Mol Cell 2017; 68(3):504-514. PubMed & PDF
    
    
45. Tang L, Morris J, Wan, J, Moore C, Fujita Y, Gilaspie S, Aube E, Nanda J, Marques M, Jangal M, Anderson A, Cox C, Hiraishi H, Dong L, Saito H, Singh CR, Witcher M, Topisirovic I, Qian SB, and Asano K*. Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide. Nucleic Acids Res 2017; 45(20):11941-11953. PubMed & PDF
    
    2016
    
    
46. Saikia M, Wang X, Mao Y, Wan J, Pan T and Qian SB. Codon optimality controls differential mRNA translation during amino acid starvation. RNA 2016; 22(11):1719-1727. &
    QQ QQ
47. Liu B and Qian SB. Characterizing inactive ribosomes in translational profiling. Translation 2016; 4(1):e1138018 &
    
    
48. Qian SB. Step back for seminal translation. Nat Struct Mol Biol 2016; 232(5):362-3. PubMed & PDF
    
    
49. Zhou J, Rode KA and Qian SB. m6A: a novel hallmark of translation. Cell Cycle 2016; 15(3):309-10&
    QQ
50. Gao X, Wan J, and Qian SB. Genome-wide profiling of alternative translation initiation sites. Methods Mol Biol 2016; 1358:303-16 &
    
    2015
    QQ QQ
51. Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, Pestova TV, Qian SB and Jaffrey SR. 5' UTR m6A promotes cap-independent translation. Cell 2015; 163(4):999-1010 &
    

    Preview in Cell

    QQ QQ
52. Zhou J, Wan J, Gao, X, Zhang X, Jaffrey SR and Qian SB. Dynamic m6A mRNA methylation directs translational regulation of heat shock response. Nature 2015; 526(7574):591-4 &
    

    Highlighted in Nat Chem Biol

    Recommended by Faculty 1000

    Q QQ
53. Wei S and Qian SB. Ribosome profiling: principles and variations. In eLS 2015 John Wiley & Sons, Ltd. Online
    QQ QQ
54. Zhang X, Gao X, Coots RA, Conn CS, Liu B and Qian SB. Translational control of cytosolic stress response by mitochondrial ribosomal protein L18. Nat Struct Mol Biol 2015; 22(5):404-10 &
    

    Featured on News and Views Nat Struct Mol Biol

    Highlighted in Science

    QQ QQ
55. Bettencourt C, de Yébenes JG, López-Sendón JL, Shomroni O, Zhang X, Qian SB, Bakker IM, Heetveld S, Ros R, Quintáns B, Sobrido MJ, Bevova MR, Jain S, Bugiani M, Heutink P, Rizzu P. Clinical and Neuropathological Features of Spastic Ataxia in a Spanish Family with Novel Compound Heterozygous Mutations in STUB1. Cerebellum 2015; 14(3)378-81 &
    QQ QQ
56. Gao X, Wan J, Liu B, Ma M, Shen B, and Qian SB. Quantitative profiling of initiating ribosomes in vivo. Nature Methods 2015; 12(2):147-53 &
    

    Highlighted in Nat Rev Mol Cell Biol

    Highlighted on ebiotrade.com

    
    2014
    QQ QQ
57. Han Y, Gao X, Liu B, Wan J, Zhang X, and Qian SB. Ribosome profiling reveals sequence-independent post-initiation pausing as a signature of translaion. Cell Res 2014; 24(7):842-51 &
    QQ
    
58. Wan J and Qian SB. TISdb: a database for alternative translation initiation in mammalian cells. Nucleic Acids Res 2014; 42(1):D845-50 &
    
    2013
    QQ QQ Q QQ
59. Liu B and Qian SB. Translational reprogrammin in cellular stress response. WIREs RNA 2013;5(3):301-15 &
    QQ QQ
60. Sherman MY and Qian SB. Less is more: Improving proteostasis by translation slow-down. Trends Biochem Sci 2013; 38(12):585-91 &
    QQ QQ
61. Conn CS and Qian SB. mTORC1 in protein homeostasis: increase in protein quantity at the expense of quality. Sci Signal 2013; 6(271):ra24 &
    

    Recommended by Faculty 1000

    Editor's choice in Science

    QQ QQ
62. Liu B, Han Y, and Qian SB. Co-translational response to proteotoxic stress by elongation pausing of ribosomes. Mol Cell 2013; 49(3):453-463. &
    

    	Featured on the cover (web) (image)			Highlighted in Nat Rev Genetics and Nat Struct Mol Biol
    	Recommended by Faculty 1000

    
    2012
    QQ QQ
63. Liu B, Conn CS, and Qian SB. Viewing co-translational folding from translating ribosomes. Expert Rev Proteomics 2012; 9(6):579-81. &
    QQ QQ
64. Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS. Decoding human cytomegalovirus. Science 2012; 338(6110):1088-93. [PubMed] [PDF]
    QQ QQ
65. Lee S, Liu B, Lee S, Huang SX, Shen B, and Qian SB. Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proc Natl Acad Sci USA. 2012; 109(37):E2424-32. [PubMed] [PDF] [Chronicle News]
    

    Highlighted on GenomeWeb (web)

    QQ QQ QQ QQ
66. Han Y, David A, Liu B, Magadán JG, Bennink JR, Yewdell JW, and Qian SB. Monitoring co-translational protein folding in mammalian cells at codon resolution. Proc Natl Acad Sci USA. 2012; 109(31):12467-72. [PubMed] [PDF]
    QQ QQ
67. Park WJ, Kothapalli KS, Reardon HT, Lawrence P, Qian SB, Brenna JT. A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids. J Lipid Res 2012; 53(8):1502-12 [PubMed] [PDF]
    
    2011
    QQ QQ
68. Liu B, and Qian SB. Translational regulation in nutrigenomics. Adv Nutr 2011; 2(6):511-9 [PubMed] [PDF]

    Highlighted on the cover (web) (image)

    QQ QQ
69. Zhang X, and Qian SB. Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresome. Mol Biol Cell 2011; 22(18):3277-88 [PubMed] [PDF]
    QQ QQ
70. Conn CS, and Qian SB. Invited review: Nutrient signaling in protein homeostasis. Cell Cycle 2011; 10(12):1940-7 [PubMed] [PDF]
    QQ QQ
71. Sun J, Conn CS, Han Y, Yeung V, and Qian SB. PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 mRNA translation.  J Biol Chem 2011 ; 286(8):6791-800 [PubMed] [PDF]
    
    Prior 2010 prior
    QQ QQ
72. Qian SB, Zhang X, Sun J, Bennink JR, Yewdell JW, Patterson C. mTORC1 links protein quality and quantity control by sensing chaperone availability.  J Biol Chem 2010 ; 285 [PubMed] [PDF]
    

    Paper of the week (JBC)

    Editor's choice (Science Signaling)

    QQ QQ
73. Qian SB, Waldren L, Choudhary N, Klevit RE, Chazin WJ, Patterson C. Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer. J Biol Chem 2009 ; 284(39):26797-802 [PubMed] [PDF]