Summary of Research
How do cells sense nutrients? How is protein synthesis coordinated with cell growth? How do cells respond to environmental stress as well as intracellular protein misfolding? These are a few of the problems we would like to understand.
Using biochemical, genetic, and cell biological approach, our laboratory investigates adaptive stress response and nutrient signaling pathways at both cellular and organismal levels. Mainly based on mammalian cells and mouse models, our research has broad implications in human diseases, including cancer, diabetes, and neurodegenerative disorders.
|
Nutrients signaling: the mammalian target of rapamycin (mTOR) |
|
Stress response: heat shock proteins and global chaperone network (HSR) |
|
Protein quality control: ubiquitin/proteasome system (UPS) |
|
