Search Cornell
Welcome to Cornell University
Welcome to Dr. Qian's laboratory
Mysteries of protein folding
 
Home
Research
 
Publications
 
People
 
News
 
Resources
 
Careers
 
Join

 

Last Update:
August 13, 2017

Publications at Cornell
  1. Saikia M, Wang X, Mao Y, Wan J, Pan T and Qian SB. Codon optimality controls differential mRNA translation during amino acid starvation. RNA 2016; 22(11):1719-1727. PubMed&PDF
    QQ
    QQ
  2. Liu B and Qian SB. Characterizing inactive ribosomes in translational profiling. Translation 2016; 4(1):e1138018 PubMed&PDF
    QQ
    QQ
  3. Qian SB. Step back for seminal translation. Nat Struct Mol Biol 2016; 232(5):362-3 & PDF
    QQ
    QQ
  4. Zhou J, Rode KA and Qian SB. m6A: a novel hallmark of translation. Cell Cycle 2016; 15(3):309-10PubMed&PDF
    QQ
    QQ
  5. Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, Pestova TV, Qian SB and Jaffrey SR. 5' UTR m6A promotes cap-independent translation. Cell 2015; 163(4):999-1010 PubMed&PDF
    star Preview in Cell    
    QQ QQ
  6. Zhou J, Wan J, Gao, X, Zhang X, Jaffrey SR and Qian SB. Dynamic m6A mRNA methylation directs translational regulation of heat shock response. Nature 2015; 526(7574):591-4 PubMed&PDF
    star Highlighted in Nat Chem Biol star Recommended by Faculty 1000
    QQ QQ
  7. Gao X, Wan J, and Qian SB. Genome-wide profiling of alternative translation initiation sites. Methods Mol Biol 2016; 1358:303-16 PubMed&PDF
    QQ
    QQ
  8. Wei S and Qian SB. Ribosome profiling: principles and variations. In eLS 2015 John Wiley & Sons, Ltd. Online PDF
    QQ
    QQ
  9. Zhang X, Gao X, Coots RA, Conn CS, Liu B and Qian SB. Translational control of cytosolic stress response by mitochondrial ribosomal protein L18. Nat Struct Mol Biol 2015; 22(5):404-10 PubMed& PDF
    star Featured on News and Views Nat Struct Mol Biol star Highlighted in Science
    QQ QQ
  10. Bettencourt C, de Yébenes JG, López-Sendón JL, Shomroni O, Zhang X, Qian SB, Bakker IM, Heetveld S, Ros R, Quintáns B, Sobrido MJ, Bevova MR, Jain S, Bugiani M, Heutink P, Rizzu P. Clinical and Neuropathological Features of Spastic Ataxia in a Spanish Family with Novel Compound Heterozygous Mutations in STUB1. Cerebellum 2015; 14(3)378-81 PubMed& PDF
    QQ
    QQ
  11. Gao X, Wan J, Liu B, Ma M, Shen B, and Qian SB. Quantitative profiling of initiating ribosomes in vivo. Nature Methods 2015; 12(2):147-53 PubMed& PDF
    star Highlighted in Nat Rev Mol Cell Biol star Highlighted on ebiotrade.com
    QQ QQ
  12. Han Y, Gao X, Liu B, Wan J, Zhang X, and Qian SB. Ribosome profiling reveals sequence-independent post-initiation pausing as a signature of translaion. Cell Res 2014; 24(7):842-51 PubMed& PDF
    QQ
  13. Wan J and Qian SB. TISdb: a database for alternative translation initiation in mammalian cells. Nucleic Acids Res 2014; 42(1):D845-50 PubMed& PDF
    QQ QQ
    Q QQ
  14. Liu B and Qian SB. Translational reprogrammin in cellular stress response. WIREs RNA 2013;5(3):301-15 PubMed& PDF
    QQ QQ
  15. Sherman MY and Qian SB. Less is more: Improving proteostasis by translation slow-down. Trends Biochem Sci 2013; 38(12):585-91 PubMed& PDF
    QQ QQ
  16. Conn CS and Qian SB. mTORC1 in protein homeostasis: increase in protein quantity at the expense of quality. Sci Signal 2013; 6(271):ra24 PubMed & PDF
    star Recommended by Faculty 1000 star Editor's choice in Science
    QQ QQ
  17. Liu B, Han Y, and Qian SB. Co-translational response to proteotoxic stress by elongation pausing of ribosomes. Mol Cell 2013; 49(3):453-463. &
    star Featured on the cover (web) (image)   star Highlighted in Nat Rev Genetics and Nat Struct Mol Biol
    star Recommended by Faculty 1000      
    QQ QQ
  18. Liu B, Conn CS, and Qian SB. Viewing co-translational folding from translating ribosomes. Expert Rev Proteomics 2012; 9(6):579-81. &
    QQ QQ
  19. Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS. Decoding human cytomegalovirus. Science 2012; 338(6110):1088-93. [PubMed] [PDF]
    QQ QQ
  20. Lee S, Liu B, Lee S, Huang SX, Shen B, and Qian SB. Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proc Natl Acad Sci USA. 2012; 109(37):E2424-32. [PubMed] [PDF] [Chronicle News]
    star Highlighted on GenomeWeb (web)
    QQ QQ QQ QQ
  21. Han Y, David A, Liu B, Magadán JG, Bennink JR, Yewdell JW, and Qian SB. Monitoring co-translational protein folding in mammalian cells at codon resolution. Proc Natl Acad Sci USA. 2012; 109(31):12467-72. [PubMed] [PDF]
    QQ QQ
  22. Park WJ, Kothapalli KS, Reardon HT, Lawrence P, Qian SB, Brenna JT. A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids. J Lipid Res 2012; 53(8):1502-12 [PubMed] [PDF]
    QQ QQ
  23. Liu B, and Qian SB. Translational regulation in nutrigenomics. Adv Nutr 2011; 2(6):511-9 [PubMed] [PDF]
    star Highlighted on the cover (web) (image)
    QQ QQ
  24. Zhang X, and Qian SB. Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresome. Mol Biol Cell 2011; 22(18):3277-88 [PubMed] [PDF]
    QQ QQ
  25. Conn CS, and Qian SB. Invited review: Nutrient signaling in protein homeostasis. Cell Cycle 2011; 10(12):1940-7 [PubMed] [PDF]
    QQ QQ
  26. Sun J, Conn CS, Han Y, Yeung V, and Qian SB. PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 mRNA translation.  J Biol Chem 2011 ; 286(8):6791-800 [PubMed] [PDF]
    QQ QQ
  27. Qian SB, Zhang X, Sun J, Bennink JR, Yewdell JW, Patterson C. mTORC1 links protein quality and quantity control by sensing chaperone availability.  J Biol Chem 2010 ; 285 [PubMed] [PDF]
    Paper of the week (JBC) Editor's choice (Science Signaling)
    QQ QQ
  28. Qian SB, Waldren L, Choudhary N, Klevit RE, Chazin WJ, Patterson C. Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer. J Biol Chem 2009 ; 284(39):26797-802 [PubMed] [PDF]
Previous Publications
  1. McDonough H, Charles PC, Hilliard EG, Qian SB, Min JN, Portbury AL, Cyr DM, Patterson C. Stress-dependent chip/DAXX interaction suppresses the p53 apoptotic program. J Biol Chem 2009 ; 284(31): 20649-59
    QQ
  2. Xia T , Dimitropoulou C , Zeng J , Antonova GN , Snead C , Venema RC , Fulton D , Qian SB , Patterson C , Papapetropoulos A , Catravas JD . Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase. Am J Physiol Heart Circ Physiol 2007; 293:H3080-3087
    QQ
  3. Qian SB , McDonough H , Boellmann F , Cyr DM , Patterson C . CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70. Nature 2006 ; 440: 551-555
    QQ
  4. Qian SB , Reits E, Neefjes J, Deslich JM, Bennink JR, and Yewdell JW. Tight linkage between translation and MHC-class I peptide ligand generation implies specialized antigen processing for defective ribosomal products. J Immunol 2006 ; 177: 227-233
    QQ
  5. Qian SB , P rinciotta MF , Bennink JR, Yewdell JW. Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control. J Biol Chem 2006 ; 281(1):392-400
    QQ
  6. Dai Q , Qian SB , Li HH , McDonough H , Borchers C , Huang D , Takayama S , Younger JM , Ren HY , Cyr DM , Patterson C . Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. J Biol Chem 2005 ; 280(46):38673-38681
    QQ
  7. Qian SB, Bennink JR, Yewdell JW. Quantitating defective ribosome products. Methods Mol Biol. 2005;301:271-81
    QQ
  8. Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, Qian SB , Zhao H, Yu X, et al. XBP1 acts downstream of Blimp-1 to regulate ER biogenesis, oeganelle expansion, and protein synthesis during plasma cell differentiation. Immunity 2004 ; 21(1):81-93
    QQ
  9. Princiotta MF, Finzi D, Qian SB , Gibbs J, Schuchmann S, Buttgereit F, Bennink JR, Yewdell JW. Quantitating protein synthesis, degradation, and endogenous antigen processing. Immunity 2003 ; 18(3):343-354
    QQ
  10. Qian SB , Ott DE, Schubert U, Bennink JR, Yewdell JW. Fusion p roteins with COOH-terminal u biquitin a re s table and m aintain d ual f unctionality in v ivo. J Biol Chem 2002 ; 277(41):38818-38826
    QQ
  11. Xie Q, Liao D, Zhou XQ, Qian SB, Cheng SS. Transduction of primary rat hepatocytes with bicistronic retroviral vector. World J Gastroenter 2000 ; 6(5): 725-729
    QQ
  12. Qian SB , Li Y, Qian GX, and Chen SS. Efficient tumor regression induced by genetically engineered tumor cells secreting interleukin-2 and membrane-expressing allogeneic MHC class I antigen. J Cancer Res Clin Oncol 2001 ; 127(1): 27-33
    QQ
  13. Qian SB , and Chen SS. Blocked transport of soluble Kb molecules containing connecting peptide segment involved in calnexin association. Int Immunol 2000 ; 12(10): 1409-1416
    QQ
  14. Xie Q , Liao D , Zhou XQ , Qian SB , Cheng SS . Transduction of primary rat hepatocytes with bicistronic retroviral vector. World J Gastroenterol 2000 ; 6(5):725-729
    QQ
  15. Qian SB , Qian GX, and Chen SS. Enhanced immunogenecity of human hepatocellular carcinoma cells transduced with human gamma-interferon gene via retroviral vector. Acta Univ Med 2 nd Shanghai 1999 ; 11(2): 90-94
    QQ
  16. Qian SB , and Chen SS. Transduction of human hepatocellular carcinoma cell lines transduced with human gamma-interferon gene via retroviral vector. World J Gastroenter 1998 ; 4(3): 210-213
    QQ
  17. Qian SB , Zhang TF, and Chen SS. Enhanced expression of HLA class I molecules in human hepatocellular carcinoma cell lines transduced with human gamma-interferon gene. Chin Med J (Eng) 1998 ; 111(4): 319-322